0.2% IVERMECTIN DRENCH
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Pharmacological action
Ivermectin mainly has a good anthelmintic effect on nematodes and surface arthropods in vivo. Its anthelmintic mechanism is to promote the release of γ-aminobutyric acid (GABA) from presynaptic neurons, thereby opening GABA-mediated chloride channels. Ivermectin is also selective and high-affinity for glutamate-mediated chloride channels located near GABA-mediated sites in invertebrate nerve and muscle cells, thereby interfering with signal transmission between neuromuscular muscles and relaxing and paralyzing the parasite, resulting in parasite death or expulsion from the body. The inhibitory interneurons and excitatory motoneurons of C. elegans are their sites of action, while the site of action of arthropods is the neuromuscular junction. It is also effective against arthropods, such as fly maggots, mites, and lice. adult Coronaria dentata and immature parasites in pigs, is also extremely effective for Trichinella spiralis in the intestine (ineffective for intramuscular Trichinella spiralis), and also has a good control effect on pig blood lice and Sarcoptes scabiei. It is ineffective against trematodes and tapeworms.
Pharmacokinetics
The pharmacokinetics of ivermectin vary markedly depending on the animal species, dosage form, and route of administration. The bioavailability of subcutaneous injection is higher than that of oral administration, but oral administration is more rapidly absorbed than subcutaneous injection. After absorption, it can be well distributed to most tissues, but it is not easy to enter the cerebrospinal fluid. The apparent volume of distribution in sheep and pigs is 4.6 and 4 L/kg, respectively. It has a long half-life in most animals, 2 to 7 and 0.5 days in sheep and pigs, respectively. This product is metabolized in the liver, mainly hydroxylated in sheep, and mainly methylated in pigs. It is mainly excreted in the feces and less than 5% is excreted unchanged or as metabolites in the urine. In lactating dams, 5% of the dose is excreted in the milk.
Drug Interactions
Concomitant use with diethylcarbamazine may produce severe or fatal encephalopathy.
Action and use
Macrolide antiparasitic drugs. Used for control of nematode, acariasis and parasitic insect diseases in sheep and pigs.
Dosage and administration
Oral: single dose, 0.1 ml for sheep and 0.15 ml for pigs per 1 kg of body weight.
Adverse reactions
No adverse reactions have been observed when used according to the specified usage and dosage.
Precautions
(1)It is contraindicated during lactation.
(2) It should be used with caution in sows during the first 45 days of pregnancy.
(3) Ivermectin shrimp, fish and aquatic organisms are highly toxic, and packaging and containers of residual drugs must not contaminate water sources.
Withdrawal period: 35 days for sheep and 28 days for pigs.
Withdrawal period
35 days for sheep and 28 days for pigs.
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
