0.5% Eprinomectin Pour on Solution
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Pharmacological action
Eprinomectin belongs to macrolide insecticides, which have a highly effective anthelmintic effect on internal and external parasites, especially nematodes and arthropods, by increasing the release of γ-aminobutyric acid (γ-GABA), an inhibitory transmitter of the parasite, as well as opening glutamate-controlled chloride channels, enhancing the permeability of the nerve membrane to chloride ions so as to block the transmission of nerve signals, ultimately leading to nerve paralysis of the parasite and loss of contractile ability of muscle cells and death.
Pharmacological action
Eprinomectin is soluble, and its pharmacokinetics show nonlinear characteristics. When 0.5 mg/kg · bw was poured on the back of dairy cows, the peak concentration (Cmax) was 18.64 ± 2.51 ng/ml, and the time to peak concentration (Tmax) was 3.63 ± 0.92 days, mean residence time (MRT) 5.61 ± 0.45 days, area under the curve (AUC0-t) 113.90 ± 19.01 ng · day ml, apparent volume of distribution (Vd) 41 L, plasma clearance (CL) 4.5 L/day, mainly excreted in feces, and a small amount excreted in milk and urine.
Indication
Eprinomectin Pour on solution is used for the treatment of parasitic diseases such as nematodes and mites in vitro in dairy cows.
Dosage And Administration
Calculated as Eprinomectin. For external use, gradually pour 0.5 mg of cattle per 1 kg of body weight along the dorsal ridge of dairy cows from the nail to the base of the tail (i.e., 1 ml of this product per 10 kg of body weight).
Precautions
1. for external use in livestock only. Do not apply to areas of skin with scabies, skin lesions, mud, and feces.
2. If the product is frozen, it should be completely thawed and shaken well before use.
3. Avoid exposure of children to drugs.
4. Used drug bottles and residual drug liquid shall be safely disposed (such as burial).
Adverse reactions
When used at the specified dose, no adverse reactions were observed.
Withdrawal period
0 days.
Package
200ml/bottle, 1L/bottle, 2L/bottle, 5L/bottle
Storage
Store in sealed condition below 30℃, protected from light.
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
