10% Enrofloxacin Oral Solution
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Composition
100ml contains 10g Enrofloxacin
Appearance
This product is almost colorless to yellowish clear liquid
Pharmacological action
Empagliflozin is a broad-spectrum bactericidal drug dedicated to fluoroquinolones. It has a good effect on Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelothrix, Proteus, Serratia marcescens, Corynebacterium pyogenes, Potter septicum, Staphylococcus aureus, Mycoplasma, and Chlamydia, a weak effect on Pseudomonas aeruginosa and Streptococcus, and a weak effect on anaerobic bacteria. It has a significant post-antibacterial effect on susceptible bacteria. The antibacterial mechanism of action of this product is to inhibit bacterial DNA gyrase, interfere with the replication, transcription and repair and recombination of bacterial DNA, and the bacteria cannot grow and multiply normally and die.
Pharmacokinetics
This product is well absorbed after oral administration in most animals. The bioavailability of oral administration in chickens is 62.2% ~ 84%, which is widely distributed in poultry and can well enter tissues and body fluids (including bones). Except for cerebrospinal fluid, the drug concentration in almost all tissues is higher than that in plasma. Hepatic metabolism is mainly to remove the ethyl group of 7-piperazine ring to generate ciprofloxacin, followed by oxidation and glucuronic acid conjugation. It is mainly excreted by the kidneys (with tubular secretion and glomerular filtration), and 15% to 50% is excreted unchanged in the urine. The elimination half-life of this product after oral administration in chickens is 9.1 to 14.2 hours
Drug interactions
(1) This product has a synergistic effect in combination with aminoglycosides or broad-spectrum penicillins.
Heavy metal ions such as Ca2 +, Mg2 +, Fe3 + and Al3 + can chelate with this product and affect absorption.
(2)When used in combination with theophylline and caffeine, the plasma protein binding rate can be reduced, the concentrations of theophylline and caffeine can be abnormally increased, and even the symptoms of theophylline poisoning can occur.
(3)This product has the effect of inhibiting hepatic drug enzymes, which can reduce the clearance rate of drugs mainly metabolized in the liver and increase the plasma concentration.
(4)Action and use: Fluoroquinolone antibacterial drugs. Used for bacterial diseases and mycoplasma infection in chickens.
Dosage and administration
Mixed drink: 0.5 ~ 0.75 ml for poultry per 1 L of water.
Adverse reactions
(1) Degeneration of cartilage occurs in young animals, affecting bone development and causing lameness and pain.
(2) Digestive system reactions include loss of appetite, diarrhea, etc.
Precautions
It is contraindicated in laying hens during the laying period
Withdrawal period
Avian: 8 days
Storage
Sealed and stored, protected from light.
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
