20% Florfenicol WSP
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Pharmacodynamics
Florfenicol is a broad-spectrum amide alcohol antibiotic and a bacteriostatic agent, which acts by inhibiting the synthesis of bacterial proteins by binding to the 50S subunit of the ribosome. It has strong antibacterial activity against a variety of gram-positive and gram-negative bacteria. Pasteurella hemolytica, Pasteurella multocida, and Actinobacillus pleuropneumoniae are highly susceptible to florfenicol. The antibacterial activity of florfenicol against many microorganisms in vitro is similar to or stronger than that of thiamphenicol, and some bacteria that are resistant to amide alcohols due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be Sensitive to florfenicol.
It is mainly used for bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, such as the respiratory diseases of cattle and pigs caused by Pasteurella hemolytica, Pasteurella multocida and Actinobacillus pleuropneumoniae. Typhoid fever and paratyphoid fever caused by Salmonella, chicken cholera, pullorum, Escherichia coli, etc.; fish bacteria caused by Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas, Enteritidis, etc. Sepsis, enteritis, red skin disease, etc.
Pharmacokinetics
Oral administration of florfenicol is rapidly absorbed, and the therapeutic concentration can be reached in the blood after about 1 hour, and the peak blood concentration can be reached in 1 to 3 hours. The bioavailability is over 80%. Florfenicol is widely distributed in animals and can pass through the blood-brain barrier. It is mainly excreted in the original form from the urine, and a small amount is excreted with the feces.
Drug interactions
(1) Macrolides and lincosamides have the same target of action as this product, they are both bound to the 50S subunit of the bacterial ribosome, and can produce mutual antagonism when used in combination. (2) It may antagonize the bactericidal activity of penicillins or aminoglycosides, but it has not been demonstrated in animals.
Action and use
Amide alcohol antibiotics. For Pasteurella and Escherichia coli infections.
Usage and Dosage
Based on this product. Oral administration: per 1kg body weight, 0.1~0.15g for pigs and chickens. 2 times a day for 3 to 5 days. Fish 50~75mg. 1 time a day for 3 to 5 days.
Adverse reactions
20% Florfenicol water soluble powder has a certain immunosuppressive effect when used at a higher dose than the recommended dose.
Attention
(1) Chickens that lay eggs for human consumption should not be used during the egg-laying period; (2) Use with caution in breeders. It has embryotoxicity and should be used with caution in pregnant and lactating livestock; (3) It is contraindicated during vaccination or in animals with severe immunodeficiency; (4) In animals with renal insufficiency, the dose should be appropriately reduced or the dosing interval should be extended.
Withdrawal period
20 days for pigs, 5 days for chickens; 375 degree days for fish.
Storage
Keep sealed and in a dry place
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
