20% Sulphadmidines Sodium Soluble Powder
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Pharmacological Glassification
Sulphonamides and Sulphonamide Combinations.
Composistion
Sulfadimidine sodium 200mg
Sulfaquinoxaline sodium 25mg
Vitamin A 15000IU
Vitamin K3 5mg
Antibacterial mechanism
Bacteria cannot directly use the folic acid in their growth environment, but use the p-aminobenzoic acid (PABA), dihydropteridine and glutamic acid in the environment to synthesize dihydrofolate under the catalysis of the dihydrofolate synthase in the bacteria. Dihydrofolate forms tetrahydrofolate under the action of dihydrofolate reductase. Tetrahydrofolate acts as a coenzyme of one-carbon unit transferase and participates in the synthesis of nucleic acid precursors (purine, pyrimidine) (Figure 2). Nucleic acid is an essential component for the growth and reproduction of bacteria. The chemical structure of sulfa drugs is similar to that of PABA, and can compete with PABA for dihydrofolate synthase, which affects the synthesis of dihydrofolate, thus inhibiting the growth and reproduction of bacteria. Since sulfa drugs can only inhibit bacteria but have no bactericidal effect, the elimination of pathogenic bacteria in the body ultimately depends on the body's defense capabilities.
Function
Sulfonamides have inhibitory effects on many Gram-positive bacteria and some Gram-negative bacteria, Nocardia, Chlamydia and certain protozoa (such as Plasmodium and Amoeba). Among the positive bacteria, streptococcus and pneumococcus are highly sensitive; Staphylococcus and Perfringens are the moderately sensitive ones. Among the negative bacteria, the sensitive ones include meningococcus, Escherichia coli, Proteus, Shigella, Pneumoniae, and Yersinia.
Indications
Poultry :Infectious coryza, white enteritis colisepticaemia. early chick mortality and to prevent secondary bacterial infections.
Calves, Sheep and Goat: Bacterial scours, acute undifferentiated diarrhoea, joint ill andpneumonia.
Dosage and application
Poulty: 1-2 g per SLiters of drinking water continuously ofr 5-7 days.
Calves, Sheep and Goats: per 15kg body weight for 5-7days in divided dosage through feed or waters as drench.
Withdrawal period
Meat: 3 days.
Milk Eggs: days.
Storage conditions
Do not store above 30℃, protect from direct sunlight.
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
