45% Tiamulin Hydrogen Fumarate Soluble Powder
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Pharmacological effects
Pharmacodynamics Tiamulin belongs to the pleuromutilin antibiotics, and it has bactericidal effect on sensitive bacteria at high concentrations. Inhibits bacterial protein synthesis by binding to the ribosomal 50S subunit.
Tiamulin has good antibacterial activity against Mycoplasma and Treponema hyodysenteriae, and also has good antibacterial activity against most Gram-positive bacteria including Staphylococcus and Streptococcus (except Group D Streptococcus). It has a certain effect on Actinobacillus pleuropneumoniae, but has weak antibacterial activity against most Gram-negative bacteria.
Pharmacological effects
Pharmacokinetics Porcine oral administration is well absorbed. After a single dose, the bioavailability is about 85%, and the peak plasma concentration is reached within 2 to 4 hours. Drugs that enter the body are widely distributed, with the highest concentration in lung tissue. Tiamulin is extensively metabolized in the body to generate more than 20 metabolites, some of which have antibacterial activity. Tiamulin metabolites are mainly excreted in feces via bile, and about 30% are excreted in urine.
Drug interactions
(1) When used together with polyether antibiotics such as monensin, salinomycin, and methyl salinomycin, it can affect the metabolism of the above polyether antibiotics, causing slow growth, movement disorders, and paralysis in chickens ,even death.
(2) Combined use with other antibiotics (such as macrolide antibiotics and lincomycin) that can bind to the 50S subunit of bacterial ribosomes may result in reduced drug efficacy due to competition for the same site of action.
Action and use: pleuromutilin antibiotics. It is mainly used for the prevention and treatment of chronic respiratory diseases in chickens, mycoplasma pneumonia in swine, and actinobacillus pleuropneumonia, and it is also used for swine dysentery (red dysentery) and porcine proliferative enteritis (ileitis) caused by Treponema.
Usage and Dosage
based on this product. Mixed drinking: per 1L of water, 0.1~0.13g for pigs, for 5 consecutive days; 0.28~0.56g for chickens, for 3 consecutive days.
Adverse reactions
Pigs use normal doses, sometimes skin erythema. Excessive application can cause temporary salivation, vomiting and central nervous system depression in pigs.
(1) It is forbidden to use it in combination with polyether antibiotics such as monensin, salinomycin, and methyl salinomycin.
(2) Users should avoid contacting the drug with eyes and skin.
Withdrawal period
7 days for pigs, 5 days for chickens
Storage
shading, sealed, and stored in a dry place.
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
