Benzypencillin sodium powder for injection
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Pharmacological action
Pharmacological action
Penicillin is a bactericidal antibiotic with strong antibacterial activity, and its antibacterial mechanism is mainly to inhibit the synthesis of bacterial cell wall mucopeptides. Sensitive bacteria in the growth stage divide vigorously, and the cell wall is in the biosynthesis stage. Under the action of penicillin, the synthesis of mucopeptides is blocked and the cell wall cannot be formed, and the cell membrane ruptures and dies under the action of osmotic pressure.
Penicillin is a narrow-spectrum antibiotic, mainly against a variety of Gram-positive bacteria and a small number of Gram-negative cocci. The main sensitive bacteria are Staphylococcus, Streptococcus, Erysipelas suis, Corynebacterium, Clostridium tetani, Actinomycetes, Bacillus anthracis, Spirochetes, etc. Insensitive to mycobacteria, mycoplasma, chlamydia, rickettsia, nocardia, fungi and viruses.
Pharmacological action
Pharmacokinetics
After intramuscular injection of penicillin, procaine is slowly absorbed after release of penicillin by local hydrolysis. The peak time is longer and the blood concentration is lower, but the effect is longer than that of penicillin. It is limited to pathogenic bacteria that are highly sensitive to penicillin, and should not be used to treat serious infections. After procaine penicillin and penicillin sodium (potassium) are mixed and formulated into injections, the blood concentration of the drug can be increased in a short period of time, so as to give consideration to both long-acting and quick-acting. Massive injection of procaine penicillin can cause procaine poisoning.
Drug Interactions
(1) The combination of penicillin and aminoglycosides can increase the concentration of the latter in the bacteria, so it presents a synergistic effect.
(2) Fast-acting bacteriostatic agents such as macrolides, tetracyclines and amide alcohols interfere with the bactericidal activity of penicillin and should not be used together.
(3) Heavy metal ions (especially copper, zinc, mercury), alcohols, acids, iodine, oxidizing agents, reducing agents, hydroxyl compounds, acidic glucose injection or tetracycline hydrochloride injection can destroy the activity of penicillin and are compatible Taboo
(4) It should not be mixed with some drug solutions (such as chlorpromazine hydrochloride, lincomycin hydrochloride, norepinephrine tartrate, oxytetracycline hydrochloride, tetracycline hydrochloride, B vitamins and vitamin C), otherwise turbidity, flocculent solids or precipitates
Indications
Mainly used for chronic infections caused by penicillin-sensitive bacteria, such as bovine pyometra, mastitis, complex fractures, etc., and also for infections such as actinomycetes and leptospirosis
Usage and Dosage
Add sterile water for injection to make a mixed solution before use. Intramuscular injection: One dose, per 1kg body weight, 10,000 to 20,000 units for horses and cattle; 20,000 to 30,000 units for sheep, pigs, and felines; 30,000 to 40,000 units for dogs and cats. 1 time a day for 2-3 days.
Adverse reactions
(1) Mainly allergic reactions, which can occur in most livestock, but the incidence is low. The local reaction is manifested as water and pain at the injection site, and the systemic reaction is measles and rash, which can cause shock or death in severe cases.
(2) In some animals, superinfection of the gastrointestinal tract can be induced.
Precautions
(1) This product is used to treat chronic infections caused by highly sensitive bacteria.
(2) Slightly soluble in water. In case of acid, alkali or oxidizing agent, it will fail rapidly. Therefore, the injection should be prepared just before use.
(3) Pay attention to the interaction and incompatibility with other drugs, so as not to affect the efficacy of the drug.
Withdrawal period
28 days (fixed) for cattle, sheep, and pigs; 72 hours for abandoning milk
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
