10% Enrofloxacin Injection
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Pharmacological Action
Enrofloxacin is a broad-spectrum bactericidal agent for fluoroquinolone animals. For Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Porter's sepsis Bacteria, Staphylococcus aureus, Mycoplasma, Chlamydia, etc., have good effects, but have weak effects on Pseudomonas aeruginosa and Streptococcus, and weak effects on anaerobic bacteria. It has obvious antibacterial effect on sensitive bacteria. The antibacterial action mechanism of this product is to inhibit bacterial DNA gyrase and interfere with bacterial DNA replication, transcription and repair and recombination. The bacteria cannot grow and reproduce normally and die.
Pharmacokinetics
10% Enrofloxacin Injection is quickly and completely absorbed by intramuscular injection. The bioavailability of this product is 91.9% for pigs and 82% for dairy cows. It is widely distributed in animals and can enter tissues well. Except for cerebrospinal fluid, the drug concentration in almost all tissues is higher than that in plasma. Liver metabolism is mainly to remove the ethyl group of the 7-piperazine ring to produce ciprofloxacin, followed by oxidation and glucuronic acid binding. It is mainly excreted through the kidneys (through renal tubular secretion and glomerular filtration), and 15%~50% is excreted in the urine in its original form. The elimination half-life varies greatly among different species of animals and different administration routes. The elimination half-life after intramuscular injection is 5.9 hours for cows, 9.9 hours for horses, 1.5 to 4.5 hours for sheep, and 4.6 hours for pigs.
Interactions
(1) 10% Enrofloxacin injection is used in combination with aminoglycosides or broad-spectrum penicillin, which has a synergistic effect.
(2) Heavy metal ions such as Ca2+, Mg2+, Fe3+ and Al3+ can chelate with this product and affect absorption.
(3) When combined with theophylline and caffeine, it can reduce the plasma protein binding rate, abnormally increase the concentration of theophylline and caffeine in the blood, and even cause symptoms of theophylline poisoning.
(4) This product has the effect of inhibiting liver drug enzymes, which can reduce the clearance rate of drugs mainly metabolized in the liver and increase the blood drug concentration.
Function and Use
Fluoroquinolone antibacterial drugs. Used for bacterial diseases and mycoplasma infections in livestock and poultry
Dosage and administration
Intramuscular injection: one dose, per 1kg body weight, 0.025ml for cattle, sheep, and pigs; 0.025~0.05ml for dogs, cats, and rabbits. Use 1 to 2 times a day for 2 to 3 days.
Adverse reactions
(1) Degeneration of cartilage in young animals, affecting bone development and causing claudication and pain.
(2) Reactions of the digestive system include vomiting, loss of appetite, and diarrhea.
(3) Skin reactions include erythema, itching, urticaria and photosensitivity.
(4) Allergic reactions, ataxia, and seizures are occasionally seen in dogs and cats.
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
