Eprinomectin (USP)
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Eprinomectin
Eprinomectin is an abamectin used as a veterinary topical endectocide. It is a mixture of two chemical compounds, eprinomectin B1a and B1b. Eprinomectin is a highly effective, broad-spectrum, and low-residue veterinary anthelmintic drug that is the only broad-spectrum anthelmintic drug applied to lactating dairy cows without the need for milk abandonment and without the need for a rest period.
Principle of Medicine
The results of kinetic studies showed that acetylaminoavermectin can be absorbed by a variety of routes, such as oral or percutaneous, subcutaneous, and intramuscular injection, with good efficacy and rapid distribution throughout the body. However, to date, there are only two commercial preparations of acetylaminoavermectin: pouring agent and injection. Among them, the application of pouring agent in virulent animals is more convenient; while although the bioavailability of injection is high, the injection site pain is obvious and the disturbance to animals is greater. It has been found that oral absorption is superior to transdermal absorption for the control of nematodes and arthropods that feed on blood or body fluids.
Physicochemical properties
The drug substance is a white crystalline solid at room temperature, with a melting point of 173 ° C and a density of 1.23 g/cm3. Because of its lipophilic group in its molecular structure, its lipid solubility is high, it is soluble in organic solvents such as methanol, ethanol, propylene glycol, ethyl acetate, etc., has the greatest solubility in propylene glycol (greater than 400 g/L), and is almost insoluble in water. Eprinomectin is easy to photolyze and oxidize, and the drug substance should be protected from light and stored under vacuum.
Using
Eprinomectin has a good control effect in the control of internal and ectoparasites such as nematodes, hookworms, ascaris, helminths, insects and mites in various animals such as cattle, sheep, camels, and rabbits. It is mainly used for the treatment of gastrointestinal nematodes, itching mites and sarcoptic mange in livestock.
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
