30% Florfenicol Injection
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Pharmacological Action
Florfenicol is a broad-spectrum antibiotic of amide alcohol and a bacteriostatic agent. It acts by binding to the 50S subunit of the ribosome to inhibit the synthesis of bacterial protein. It has strong antibacterial activity against a variety of gram-positive and gram-negative bacteria. Pasteurella hemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae are highly sensitive to florfenicol. The antibacterial activity of florfenicol against many microorganisms in vitro is similar to or stronger than that of thiamphenicol. Some bacteria that are resistant to amide alcohols due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be resistant to fluorobenzene. Nico is sensitive. It is mainly used for bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, such as respiratory diseases of cattle and pigs caused by Pasteurella hemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae. Salmonella caused by typhoid fever and paratyphoid fever, chicken cholera, chicken pullorum, colibacillosis, etc.; fish bacterial sepsis caused by fish pasteurella, vibrio, Staphylococcus aureus, hydrophila, enteritidis, etc. Enteritis, red skin disease, etc.
Pharmacokinetics
Florfenicol is quickly absorbed by oral administration, and the therapeutic concentration can be reached in the blood after about 1 hour, and the peak blood concentration can be reached within 1 to 3 hours. The bioavailability is over 80%. Florfenicol is widely distributed in animals and can penetrate the blood-brain barrier. It is mainly excreted in urine in its original form, and a small amount is excreted in feces.
Action and Use
Amidol antibiotics. For Pasteurella and E. coli infections.
Dosage and Administration
Intramuscular injection: a single dose, 0.067 ml for chickens and 0.05 ~ 0.067 ml for pigs per 1 kg body weight. Every 48 hours for 2 doses. Fish 0.0017 ~ 0.0034ml, qd.
Adverse Reactions
1.30% Florfenicol injection has certain immunosuppressive effect when used at doses higher than the recommended dose.
2. It has embryotoxicity and should be used with caution in livestock during pregnancy and lactation.
Precautions:
1. It is contraindicated in laying hens during the laying period.
2. It is contraindicated during the vaccination period or in animals with severely compromised immune function.
3. Appropriate dose reduction or prolongation of the dosing interval is required in affected animals with renal insufficiency.
Withdrawal Period
Pig 14 days, chicken 28 days.
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
