Tiamulin Hydrogen Fumarate
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Tiamulin hydrogen fumarate
Tiamulin hydrogen fumarate is a derivative of pleuromutilin, can be used in veterinary medicine particularly for pigs and poultry.It is a diterpene antimicrobial with a pleuromutilin chemical structure similar to that of valnemulin.
Tiamulin hydrogen fumarate is white or almost white crystalline powder, odorless and tasteless. It is easily soluble in methanol or ethanol, soluble in water, slightly soluble in acetone, and almost insoluble in hexane .
Mode of action and characteristics
This product is a bacteriostatic antibiotic, but it also has bactericidal effect on sensitive bacteria at very high concentration. The antibacterial mechanism of action is to inhibit bacterial protein synthesis by binding to the 50s subunit of the bacterial ribosome.
Tiamulin hydrogen fumarate has good antibacterial activity against a variety of Gram-positive cocci, including most staphylococci and streptococci (except group D streptococci) and a variety of mycoplasmas and some spirochetes. However, the antibacterial activity against some negative bacteria is very weak, except for Haemophilus species and some E. coli and Klebsiella strains.
Tiamulin hydrogen fumarate is easy to be absorbed after oral administration in pigs. About 85% of a single dose is absorbed, and peak concentrations occur in 2 to 4 hours. It is widely distributed in the body, with the highest concentration in the lungs. Tiamulin hydrogen fumarate is metabolized in the body into 20 metabolites, some with antibacterial tranquility. About 30% of the metabolites are excreted in the urine and the remainder is excreted in the feces.
Usage
Tiamulin hydrogen fumarate is used for the treatment of swine pneumonia caused by Actinobacillus pleuropneumoniae and swine blood dysentery caused by Treponema hyodysenteriae. As a feed drug additive for pigs can promote weight gain. It is also effective against chronic respiratory disease in chickens, mycoplasma hyopneumonia, and staphylococcal synovitis in chickens.
Content
≥ 98%
Specification
USP42/ EP10
Packing
25kg/cardboard drum
Preparations
10%, 45% 80% Tiamulin hydrogen fumarate premix / soluble powder
Hebei Veyong pharmaceutical Co., Ltd, was established in 2002, located in Shijiazhuang City, Hebei Province, China, next to the Capital Beijing. She is a large GMP-certified veterinary drug enterprise, with R&D, production and sales of veterinary APIs, preparations, premixed feeds and feed additives. As Provincial Technical Center, Veyong has established an innovated R&D system for new veterinary drug, and is the nationally known technological innovation based veterinary enterprise, there are 65 technical professionals. Veyong has two production bases: Shijiazhuang and Ordos, of which the Shijiazhuang base covers an area of 78,706 m2, with 13 API products including Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, and 11 preparation production lines including injection, oral solution, powder, premix, bolus, pesticides and disinfectant, ects. Veyong provides APIs, more than 100 own- label preparations, and OEM & ODM service.
Veyong attaches great importance to the management of EHS(Environment, Health& Safety) system, and obtained the ISO14001 and OHSAS18001 certificates. Veyong has been listed in the strategic emerging industrial enterprises in Hebei Province and can ensure the continuous supply of products.
Veyong established the complete quality management system, obtained the ISO9001 certificate, China GMP certificate, Australia APVMA GMP certificate, Ethiopia GMP certificate, Ivermectin CEP certificate, and passed US FDA inspection. Veyong has professional team of registeration, sales and technical service, our company has gained reliance and support from numerous customers by excellent product quality, high-quality pre-sales and after-sales service, serious and scientific management. Veyong has made long term cooperation with many internationally known animal pharmaceutical enterprises with products exported to the Europe, South America, Middle East, Africa, Asia, etc. more than 60 countries and regions.
